Novel chemoenzymatic methodology for the regioselective glycine loading on polyhydroxy compounds.
نویسندگان
چکیده
In the present work, we have developed a highly efficient temperature-dependent chemo-enzymatic methodology for the regioselective synthesis of novel esters of glycerol, G1 tri-glycerol dendrons and related esters for the first time using 4-nitrophenyl 2-(tert-butoxycarbonyl)acetate (Boc-gly-Ph-pNO(2)) (2) as the acylating agent. This methodology offers efficient and controlled loading of amino acid (glycine) on polyhydroxy compounds.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 8 9 شماره
صفحات -
تاریخ انتشار 2010